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KMID : 0359720140320010034
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Journal of the Korean Neurological Association
2014 Volume.32 No. 1 p.34 ~ p.37
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Paraneoplastic Necrotizing Myopathy Associated With Ovarian Adenocarcinoma
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Lee Hye-Mi
Kim Ji-Sun
Kim Min-Jik
Kang Sung-Hoon
Hong Jin-Hwa
Park Sung-Hye
Kim Ji-Hyun
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Abstract
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We describe here a case of female patient who presented with mild proximal weakness, myalgia, and markedly elevated CPK, which could be ascribed to paraneoplastic necrotizing myopathy in association with ovarian adenocarcinoma. A histologic examination of the vastus lateralis muscle showed necrosis of muscle fibers without inflammatory cell infiltration. Her neurologic symptoms improved following tumor resection and systemic chemotherapy. Paraneoplastic necrotizing myopathy may be a presenting manifestation of malignancy, and early recognition and prompt treatment are crucial for the clinical improvement.
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KEYWORD
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Paraneoplastic myopathy, Necrotizing myopathy, Ovarian adenocarcinoma
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